Posts Categorized: Part 27: SKIN

Losartan therapy for dystrophic epidermolysis bullosa

Posted by & filed under Part 27: SKIN.

Genetic loss of collagen VII causes recessive dystrophic epidermolysis bullosa (RDEB)—a severe skin fragility disorder associated with lifelong blistering and disabling progressive soft tissue fibrosis. No effective therapies are available. Based on the findings that TGF-beta activity is elevated in injured RDEB skin, Nystrom and colleagues targeted TGF-beta activity with losartan in RDEB mice. Long-term treatment with […]