Tissue-based map of the human proteome

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Ulen et al. used an integrative omics approach to study the spatial human proteome. Samples representing all major tissues and organs in the human body were analyzed based on 24,028 antibodies corresponding to 16,975 protein-encoding genes, complemented with RNA-sequencing data for 32 of the tissues.

A genome-wide analysis of the tissue specificity of RNA and protein expression covering more than 90% of the putative protein-coding genes, complemented with analyses of various subproteomes(e.g. membrane-bound proteins), was performed.

A freely available interactive resource is available at www.proteinatlas.org.

Proteomics. Tissue-based map of the human proteome. Uhlén et al. Science. 2015 Jan 23;347(6220):1260419.

 

posted by Yannis Trakadis, MD

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