We are increasingly aware of the role that oxidative stress plays in cellular pathophysiology. Cardiolipin, a phospholipid abundant in the inner mitochondrial membrane, has been shown to be particularly susceptible to oxidative stress and peroxidation. This is particularly relevant due to the role that cardiolipin plays in cytochrome c activity.
A recent antioxidant compound, SS-31 (D-Arg-dimethylTyr-Lys-Phe-NH2 ), was shown to selectively bind to cardiolipin and inhibit cytochrome c peroxidase activity. SS-31 further was shown to restore cytochrome c reduction and mitochondrial oxygen utilization (Birk et al, Br J Pharmacol. 2014 Apr;171(8):2017-28).
Thus, SS-31 may represent a novel class antioxidants with cardiolipin as its’ target.
Hilary Vernon, MD PhD