Wager et al. provide an interesting overview of how zebrafish can be used as a model for inborn errors of metabolism to understand their mechanistic basis. Available methods for creating and studying zebrafish disease models, advantages and disadvantages of using this model organism, novel mechanistic insights already provided using this model, and successful examples of its use for drug discovery and development are reviewed.

Modelling inborn errors of metabolism in zebrafish. Wager K, Mahmood F, Russell C. J Inherit Metab Dis. 2014 Jul;37(4):483-95. PMID: 24797558

Posted by Yannis Trakadis, MD