False positive newborn screening can represent a significant burden both emotionally and financially. Morris et al (Genetics in Medicine, 6(16), 2014) describes a protocol designed to reduce false positive screens in infants in a neonatal intensive care unit (NICU) setting. As part of this protocol, total parenteral nutrition was replaced with dextrose/electrolyte fluid containing IV fluids for 3 h before newborn screening collection. This resulted in a 74% reduction in false-positive results in a NICU.
This simple protocol should be considered in NICUs in which a significant portion of patients are receiving total parenteral nutrition.
Hilary Vernon, MD PhD