Mitochondrial Cristae and Supercomplexes

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In a very well thought out group of experiments, Cogliati et al. demonstrated the effect that disturbed mitochondrial cristae shape has on respiratory chain supercomplexes (Cell, 155, (2013)160-171). This supercomplex effect has implications for cell growth, apoptosis, and respiratory efficiency. These studies suggest potentially interesting pathophysiological mechanisms for other disorders affecting cristae organization, such as 3-methyglutaconic aciduria type II.

Hilary Vernon, MD PhD

 

 

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