As information derived from large scale metabolomic investigations rapidly expands, organization of this data into relevant and interconnected pathways presents a very complex problem. Sahoo et al (Mol Biosyst. 2012 Oct;8(10):2545-58.) presented a very interesting approach to this problem, specifically in interconnecting missing reactions involved in fatty acid oxidation with existing models of the published human metabolic reconstruction. The resultant, more complete metabolic map was then combined with phenotypic features of related inborn errors of metabolism. This kind of analysis will prove critical in translating metabolomic studies into clinical practiice.
Hilary Vernon, MD PhD