Whole-genome sequencing of 78 parentâ€“offspring trios in Iceland was used to study the de novo genome-wide mutation rates. Fathers on average passed more de novo mutations than mothers. The overall de novo genome-wide mutation rate is reported to increase by about two mutations a year as a function of the increasing age of the father at conception. The fatherâ€™s age accounted for nearly all of the variation in the number of new mutations in a childâ€™s genome. According to Kong et al. these data may be consistent with the importance of fatherâ€™s age on the risk of diseases such as autism and schizophrenia.
Â Rate of de novo mutations and the importance of father’s age to disease risk.Â Kong et al. Nature. 2012 Aug 23;488(7412):471-5. doi: 10.1038/nature11396. PMID: 22914163
Posted by Yannis Trakadis, MD