In a forward genetic screen in C. elegans, Liu et al. identified LAAT-1, and its human counterpart PQLC2 as the lysosomal lysine/arginine transporter. Without this transporter, lysosomes become filled with arginine and lysine and this can cause cell death. Mutations in PQLC2 have not yet been identified in humans with lysosomal disorders.
Liu B, Du H, Rutkowski R, Gartner A, Wang X.
LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis.
Science. 2012 Jul 20;337(6092):351-4. PubMed PMID: 22822152.
Posted by Philippe Campeau, M.D.