Exome and whole genome sequencing by next generation sequencingÂ have shown tremendous potentialÂ for discovery ofÂ genes underlying Mendelian disorders. To accelerate these discoveries, the National Institutes of Health has established three Centers for Mendelian Genomics (CMGs): the Center
for Mendelian Genomics at the University of Washington; the Center for MendelianÂ Genomics at Yale University; and the Baylorâ€“Johns Hopkins Center for MendelianÂ Genomics at Baylor College of Medicine and Johns Hopkins University. The CMGs will collaborateÂ with the global genetics community to discoverÂ genes for Mendelian phenotypes which have yet to be uncovered.Â Further information are available in the JulyÂ 2012Â issue of the Am J Med Genet part A (158 issue 7 pages 1523â€“1525)Â and at http://mendelian.org.
Nicola Brunetti-Pierri, MD