Targeting nuclear RNA to the mitochondria

Posted by & filed under Part 10: DISORDERS OF MITOCHONDRIAL FUNCTION.

A group headed by Dr. Carla M. Koehler at UCLA has just published the use of an RNA stem-loop sequence from H1 RNA, the RNA component of the human RNase P enzyme, to target other nuclear encoded RNAs to the mitochondria. They demonstrated a potential therapeutic use by modifying the mt-tRNAs with this sequence, encode them in the nucleus of cells from MELAS and MERFF patients with mutations in these mt-tRNAs, and partially correcting the respiration defect in these cells.

Wang G et al. Correcting human mitochondrial mutations with targeted RNA import. Proc Natl Acad
Sci U S A. 2012 Mar 27;109(13):4840-5

Posted by Philippe Campeau, MD

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