A recentÂ case report by Traber et al in the Journal of Neuroopthalmology (August 25,Â 2011 Epub)Â describes an adult patient with methylmalonic acidemia (MMA)Â and sudden onset of bilateral vision loss with optic atrophy.Â This may not be commonly though of as a frequent adultÂ complicationÂ of MMA. However, this sudden onset of vision loss hasÂ been described before in adults withÂ methylmalonic acidemiaÂ (MMA) and propionic acidemia (MMA). The largest cohort reportedÂ includes 2 adults with MMA and one adult withÂ PAÂ by Williams et al, in the American Journal of Ophthalmology (2009) 147(5): 929-33.
Hilary Vernon, MD PhD
DOI Reference Number : http://dx.doi.org/10.1036/ommbid.121