neuropsych functions in adults with early treated PKU

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Patients with PKU treated early have been reported to have deficits in several frontal lobe-related neuropsychological tasks such as the Stroop task. This study compared 17 adult male patients with early-treated classic PKU to 15 male healthy controls using a Color-word matching Stroop task in a functional magnetic resonance imaging (fMRI) study at 3T. Participants were scanned twice, and an oral Phe load (100 mg/kg body weight) was administered prior to one of the fMRI sessions. Activity in brain regions known to be involved in Stroop tasks was assessed. PKU patients exhibited poorer accuracy in incongruent trials. The oral Phe administration had no significant effect on brain activity. The authors did not find evidence to support a slower task performance or altered functioning of brain networks involved in executive functions.  (Sundermann et al. J Inherit Metab Dis. 2011 Jun;34(3):711-21.) 

Posted by Yannis Trakadis, MD MSc

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