Disorders of selenium metabolism

Posted by & filed under Part 14: METALS.

A review of  disorders of selenium metabolism and selenoproteins was recently publised in Current Opinion in Pediatrics. It includes up to date descriptions of SECISBP2 syndrome, causing thyroid dysfunction and growth retardation, and SEPSECS mutations causing progressive cerebellar and cerebral atrophy. Other abnormalities seen in impaired selenium metabolism include impaired muscle function, and immune deficits.

(Schweizer et al, Current Opinion in Pediatrics, 2011, 23:June 8, epub.)

Posted by Hilary Vernon MD PhD

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