Ashe K.M. et al. Â Inhibition of glycogen biosynthesis via mTORC1 suppression as an adjunct therapy for Pompe disease. Molecular Genetics and Metabolism Volume 100, Issue 4, August 2010, Pages 309-315
This study reported that co-administration of the mTORC1 inhibitor rapamycin with Recombinant human GAA (rhGAA) in a GAA knockout mouse reduced muscle glycogen content more than rhGAA or rapamycin alone.
posted by Yannis Trakadis