IDH1 mutation in gliomas

Posted by & filed under Part 04: CANCER, Part 10: DISORDERS OF MITOCHONDRIAL FUNCTION.

Certain gliomas have somatic mutation in cytosolic isocitrate dehydrogenase 1. Dang et al. have shown that these mutations confer the enzyme the new ability to transform alpha-ketoglutarate in 2-hydroxyglutarate. This metabolite might be oncogenic, although this is not proven yet.

Dang L, White DW, Gross S, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 2009;462:739-744

Philippe Campeau

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